Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL.

Antzeko izenburuak

• The pVHL-hIF-1 system. A key mediator of oxygen homeostasis.
  nork: Maxwell, P, et al.
  Argitaratua: (2001)
• Chemical basis for the selectivity of the von Hippel Lindau tumor suppressor pVHL for prolyl-hydroxylated HIF-1alpha.
  nork: Illingworth, C, et al.
  Argitaratua: (2010)
• Regulation of the HIF pathway: enzymatic hydroxylation of a conserved prolyl residue in hypoxia-inducible factor alpha subunits governs capture by the pVHL E3 ubiquitin ligase complex.
  nork: Mole, D, et al.
  Argitaratua: (2002)
• Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth.
  nork: Keiichi Kondo, et al.
  Argitaratua: (2003-12-01)
• The interaction between the von Hippel-Lindau gene product (pVHL) and hypoxia-inducible factor 1 is disrupted by disease-causing pVHL mutants.
  nork: Maher, E, et al.
  Argitaratua: (1999)