Assessment of repurposed compounds against coronaviruses highlights the antiviral broad-spectrum activity of host-targeting iminosugars and confirms the activity of potent directly acting antivirals
The COVID-19 pandemic highlights the need for novel antiviral drug discovery approaches that could dramatically shorten timelines from compound discovery to clinical development. At the beginning of the pandemic, repurposing approaches were at the forefront of early research efforts to screen for an...
Autors principals: | Brun, J, Arman, BY, Hill, ML, Kiappes, JL, Alonzi, DS, Makower, LL, Witt, KD, Gileadi, C, Rangel, V, Dwek, RA, Von Delft, A, Zitzmann, N |
---|---|
Format: | Journal article |
Idioma: | English |
Publicat: |
Elsevier
2025
|
Ítems similars
-
Iminosugar antivirals: the therapeutic sweet spot
per: Alonzi, D, et al.
Publicat: (2017) -
Antiviral effects of deoxynojirimycin (DNJ)-based iminosugars in dengue virus-infected primary dendritic cells
per: Perera, N, et al.
Publicat: (2022) -
Antiviral effects of an iminosugar derivative on flavivirus infections.
per: Wu, S, et al.
Publicat: (2002) -
Mechanisms of antiviral activity of iminosugars against dengue virus
per: Miller, JL, et al.
Publicat: (2018) -
Inhibition of endoplasmic reticulum glucosidases is required for in vitro and in vivo dengue antiviral activity by the iminosugar UV-4
per: Warfield, KL, et al.
Publicat: (2016)