$Whole‐genome sequencing identifies EN1 as a determinant of bone density and fracture$

Whole‐genome sequencing identifies EN1 as a determinant of bone density and fracture

The extent to which low‐frequency (minor allele frequency (MAF) between 1–5%) and rare (MAF ≤ 1%) variants contribute to complex traits and disease in the general population is mainly unknown. Bone mineral density (BMD) is highly heritable, a major predictor of osteoporotic fractures, and has been p...

書誌詳細
主要な著者:	Zheng, H, Forgetta, V, Hsu, Y-H, Estrada, K, Rosello-Diez, A, Leo, PJ, Dahia, C, Park-Min, K, Tobias, J, Kooperberg, C, Kleinman, A, Styrkarsdottir, U, Liu, C, Uggla, C, Evans, D, Nielson, C, Walter, K, Pettersson-Kymmer, U, McCarthy, S, Eriksson, J, Kwan, T, Jhamai, M, Trajanoska, K, Memari, Y, Min, J, Huang, J, Danecek, P, Wilmot, B, Li, R, Chou, W, Mokry, L, Moayyeri, A, Claussnitzer, M, Cheng, C, Cheung, W, Medina-Gómez, C, Ge, B, Chen, S, Choi, K, Oei, L, Fraser, J, Kraaij, R, Hibbs, M, Gregson, C, Paquette, D, Hofman, A, Wibom, C, Tranah, G, Marshall, M, Gardiner, B, Cremin, K, Auer, P, Hsu, L, Ring, S, Tung, J, Thorleifsson, G, Enneman, A, van Schoor, N, de Groot, L, van der Velde, N, Melin, B, Kemp, J, Christiansen, C, Sayers, A, Zhou, Y, Calderari, S, van Rooij, J, Carlson, C, Peters, U, Berlivet, S, Dostie, J, Uitterlinden, A, Williams, S, Farber, C, Grinberg, D, LaCroix, A, Haessler, J, Chasman, D, Giulianini, F, Rose, L, Ridker, P, Eisman, J, Nguyen, T, Center, J, Nogues, X, Garcia-Giralt, N, Launer, L, Gudnason, V, Mellström, D, Vandenput, L, Amin, N, van Duijn, C, Karlsson, M, Ljunggren, Ö, Svensson, O, Hallmans, G, Rousseau, F, Giroux, S, Bussière, J, Arp, P, Koromani, F, Prince, R, Lewis, J, Langdahl, B, Hermann, A, Jensen, J, Kaptoge, S, Khaw, K, Reeve, J, Formosa, M, Xuereb-Anastasi, A, Åkesson, K, McGuigan, F, Garg, G, Olmos, J, Zarrabeitia, M, Riancho, J, Ralston, S, Alonso, N, Jiang, X, Goltzman, D, Pastinen, T, Grundberg, E, Gauguier, D, Orwoll, E, Karasik, D, Davey-Smith, G, Smith, A, Siggeirsdottir, K, Harris, T, Zillikens, M, van Meurs, J, Thorsteinsdottir, U, Maurano, M, Timpson, N, Soranzo, N, Durbin, R, Wilson, S, Ntzani, E, Brown, M, Stefansson, K, Hinds, D, Spector, T, Cupples, L, Ohlsson, C, Greenwood, C, Jackson, R, Rowe, D, Loomis, C, Ackert-Bicknell, C, Joyner, A, Duncan, E, Kiel, D, Rivadeneira, F, Richards, J
フォーマット:	Journal article
言語:	English
出版事項:	Nature Publishing Group 2015

類似資料

Differences in Voluntary Cow Traffic between Holstein and Illawarra Breeds of Dairy Cattle in a Pasture-based Automatic Milking System
著者:: C. E. F. Clark, 等
出版事項: (2014-04-01)

Información bibliográfica
著者:: A. M. C., 等
出版事項: (2001-12-01)

Información bibliográfica
著者:: C.G.A., G.G.D., J.M.A., J.C.R.S., J.M.M., A.G.C., J.I.U.
出版事項: (1995-04-01)

Graded response model fit, measurement invariance and (comparative) precision of the Dutch-Flemish PROMIS® Upper Extremity V2.0 item bank in patients with upper extremity disorders
著者:: C. M. Lameijer, 等
出版事項: (2020-03-01)

Effect of calcium addition and pH on yield and texture of Minas cured cheese
著者:: B.N.C. Santos, 等
出版事項: (2013-04-01)

Información Bibliográfica
著者:: G. C.V., 等
出版事項: (2001-04-01)

A thermodynamic model of the cardiac sarcoplasmic/endoplasmic Ca2+ (SERCA) pump
著者:: K., T, 等
出版事項: (2008)

The DeepMIP contribution to PMIP4: methodologies for selection, compilation and analysis of latest Paleocene and early Eocene climate proxy data, incorporating version 0.1 of the DeepMIP database
著者:: C. J. Hollis, 等
出版事項: (2019-07-01)

Effect of Phenological Growth Stage on Establishment of In-vitro Cultures of Bael (<i>Aegle marmelos</i> (L.) Corr.)
著者:: C. K. Pathirana, 等
出版事項: (2018-06-01)

An improved low-power measurement of ambient NO<sub>2</sub> and O<sub>3</sub> combining electrochemical sensor clusters and machine learning
著者:: K. R. Smith, 等
出版事項: (2019-02-01)

The hypoxia-sensor carbonic anhydrase IX affects macrophage metabolism, but is not a suitable biomarker for human cardiovascular disease
著者:: J. A. F. Demandt, 等
出版事項: (2021-01-01)

Información Bibliográfica
著者:: M.M.L, S.M.E., J.R.F, L.L.G.C., A.V.V., E.O.S., M.T.D., G.G.D., A.M.C., J.L.R.M., RA.R., A.G.C., A.G.E., R. de M., J.F.B.
出版事項: (1996-02-01)

Widespread trace bromine and iodine in remote tropospheric non-sea-salt aerosols
著者:: G. P. Schill, 等
出版事項: (2025-01-01)

DETECÇÃO DE BACTEREMIA POR STREPTOCCOCUS GALLOLYTICUS EM DOADOR DE PLAQUETAFÉRESE – RELATO DE CASO
著者:: C.M. Wink, 等
出版事項: (2020-11-01)

Applicability of semi quantitative approach to assess the potential environmental risks for sustainable implementation of water supply schemes: a case study of Sri Lanka
著者:: B. K. A. Bellanthudawa, 等
出版事項: (2021-06-01)

Información Bibliográfica
著者:: A.M.C., M.T.D., A.G.C., S.F.M., J.F.B, J.I.U., A.J.V.V.
出版事項: (1996-06-01)

Intravenous polyionic solution with a high concentration of lactate (84 mEq/L) is effective for the treatment of diarrheal calves
著者:: J.A.N. Lisbôa, 等
出版事項: (2024-08-01)

P5.08 NORMALISATION FOR WALL SHEAR STRESS STIMULUS IMPROVES ACCURACY IN THE ASSESSMENT OF GLUCOSE-INDUCED CHANGES IN FLOW-MEDIATED DILATION
著者:: F.C.G. van Bussel, 等
出版事項: (2011-11-01)

Información bibliográfica
著者:: J.F.B., J.J.D., J.L.L.G., J.Ma.A.O., J.Ma.A.O., A.M.C., S.F.R., A.G.C.
出版事項: (1997-12-01)

Conceptual designs of two petawatt-class pulsed-power accelerators for high-energy-density-physics experiments
著者:: W. A. Stygar, 等
出版事項: (2015-11-01)

CONTRIBUIÇÃO DE UMA LIGA DE HEMATOLOGIA PARA A FORMAÇÃO ACADÊMICA NO CURSO DE MEDICINA EM UMA UNIVERSIDADE DA BAHIA: RELATO DE EXPERIÊNCIA
著者:: A.V.C. Codeceira, 等
出版事項: (2020-11-01)

Age, pathology and CA-125 are prognostic factors for survival in patients with brain metastases from gynaecological tumours
著者:: S.H.J. Nagtegaal, 等
出版事項: (2020-09-01)

Mitigation of the effects of salt stress in cowpea bean through the exogenous aplication of brassinosteroid
著者:: D. J. P. Sousa, 等
出版事項: (2022-07-01)

Optimisation of geometric aspect ratio of thin film transistors for low-cost flexible CMOS inverters and its practical implementation
著者:: N. C. A. van Fraassen, 等
出版事項: (2022-09-01)

Hydrogel improves the initial growth and quality of Enterolobium contortisiliquum seedlings
著者:: L. K. S. Silva, 等
出版事項: (2019-06-01)

PERFIL DA ANEMIA FERROPRIVA E SEUS DESFECHOS NO ESTADO DA BAHIA: ESTUDO SOCIOEPIDEMIOLÓGICO
著者:: L.D.S. Silva, 等
出版事項: (2020-11-01)

Investigating biomass burning aerosol morphology using a laser imaging nephelometer
著者:: K. M. Manfred, 等
出版事項: (2018-02-01)

MAPPING PASTURE AREAS IN WESTERN REGION OF SÃO PAULO STATE, BRAZIL
著者:: A. F. C. Bonamigo, 等
出版事項: (2020-10-01)

LAND USE/LAND COVER CLASSIFICATION IN A HETEROGENEOUS AGRICULTURAL LANDSCAPE USING PLANETSCOPE DATA
著者:: I. T. Bueno, 等
出版事項: (2023-04-01)

The sustainability of habitability on terrestrial planets: Insights, questions, and needed measurements from Mars for understanding the evolution of Earth-like worlds
著者:: Ehlmann, B. L., 等
出版事項: (2018)

OH reactivity in a South East Asian tropical rainforest during the Oxidant and Particle Photochemical Processes (OP3) project
著者:: P. M. Edwards, 等
出版事項: (2013-09-01)

AUGMENTING THE PHILIPPINES’ DOST-ASTI’S POTENTIAL FLOOD EXTENTS MAPPING SERVICE WITH S-BAND NOVASAR-1 IMAGES
著者:: J. B. L. C. Dumalag, 等
出版事項: (2024-04-01)

P640: PIRTOBRUTINIB, A HIGHLY SELECTIVE, NON-COVALENT (REVERSIBLE) BTK INHIBITOR IN COMBINATION WITH VENETOCLAX±RITUXIMAB IN RELAPSED/REFRACTORY CLL: RESULTS FROM THE BRUIN PHASE 1B STUDY
著者:: L. E. Roeker, 等
出版事項: (2022-06-01)

Información Bibliográfica
著者:: A.G.C., J.F.B., G.G.D., J.I.U., G.C.V.
出版事項: (1997-02-01)

Kelvin-Helmholtz Vortices as an Interplay of Magnetosphere-Ionosphere Coupling
著者:: K.-J. Hwang, 等
出版事項: (2022-06-01)

Quantifying the loss of processed natural gas within California's South Coast Air Basin using long-term measurements of ethane and methane
著者:: D. Wunch, 等
出版事項: (2016-11-01)

Información Bibliográfica
著者:: J.Mª.A.O., J.D.A., J.R.F., A.M.C., J.F.B., J.L.R.M., M.M.L.
出版事項: (1995-12-01)

Ambient aerosol properties in the remote atmosphere from global-scale in situ measurements
著者:: C. A. Brock, 等
出版事項: (2021-10-01)

Second assessment of NeuroAIDS in Africa.
著者:: Robertson, K, 等
出版事項: (2008)

Ice supersaturations exceeding 100% at the cold tropical tropopause: implications for cirrus formation and dehydration
著者:: E. J. Jensen, 等
出版事項: (2005-01-01)