The length of lipids bound to human CD1d molecules modulates the affinity of NKT cell TCR and the threshold of NKT cell activation.
CD1d-restricted lymphocytes recognize a broad lipid range. However, how CD1d-restricted lymphocytes translate T cell receptor (TCR) recognition of lipids with similar group heads into distinct biological responses remains unclear. Using a soluble invariant NKT (iNKT) TCR and a newly engineered antib...
Автори: | McCarthy, C, Shepherd, D, Fleire, S, Stronge, V, Koch, M, Illarionov, P, Bossi, G, Salio, M, Denkberg, G, Reddington, F, Tarlton, A, Reddy, BG, Schmidt, R, Reiter, Y, Griffiths, G, Van Der Merwe, P, Besra, G, Jones, E, Batista, F, Cerundolo, V |
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Формат: | Journal article |
Мова: | English |
Опубліковано: |
2007
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