Fibroblasts as efficient antigen-presenting cells in lymphoid organs.

Fibroblasts as efficient antigen-presenting cells in lymphoid organs.

Only so-called "professional" antigen-presenting cells (APCs) of hematopoietic origin are believed capable of inducing T lymphocyte responses. However, fibroblasts transfected with viral proteins directly induced antiviral cytotoxic T lymphocyte responses in vivo, without involvement of ho...

תיאור מלא

מידע ביבליוגרפי
Main Authors: Kündig, T, Bachmann, M, DiPaolo, C, Simard, J, Battegay, M, Lother, H, Gessner, A, Kühlcke, K, Ohashi, P, Hengartner, H
פורמט: Journal article
שפה:English
יצא לאור: 1995
תיאור
סיכום:Only so-called "professional" antigen-presenting cells (APCs) of hematopoietic origin are believed capable of inducing T lymphocyte responses. However, fibroblasts transfected with viral proteins directly induced antiviral cytotoxic T lymphocyte responses in vivo, without involvement of host APCs. Fibroblasts induced T cells only in the milieu of lymphoid organs. Thus, antigen localization affects self-nonself discrimination and cell-based vaccine strategies.

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