Cis-acting sequences regulating expression of the human alpha-globin cluster lie within constitutively open chromatin.

Cis-acting sequences regulating expression of the human alpha-globin cluster lie within constitutively open chromatin.

Current models suggest that tissue-specific genes are arranged in discrete, independently controlled segments of chromatin referred to as regulatory domains. Transition from a closed to open chromatin structure may be an important step in the regulation of gene expression. To determine whether the h...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों:	Vyas, P, Vickers, M, Simmons, D, Ayyub, H, Craddock, C, Higgs, D
स्वरूप:	Journal article
भाषा:	English
प्रकाशित:	1992

समान संसाधन

Contrasting effects of alpha and beta globin regulatory elements on chromatin structure may be related to their different chromosomal environments.
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Alpha-thalassemia caused by a large (62 kb) deletion upstream of the human alpha globin gene cluster.
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Conservation of position and sequence of a novel, widely expressed gene containing the major human alpha-globin regulatory element.
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प्रकाशित: (1995)

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प्रकाशित: (2013)

High-resolution analysis of cis-acting regulatory networks at the α-globin locus.
द्वारा: Hughes, J, और अन्य
प्रकाशित: (2013)

GEOGRAPHIC-DISTRIBUTION OF ALPHA-GLOBIN AND BETA-GLOBIN GENE-CLUSTER POLYMORPHISMS
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Analysis of DNA Methylation at the Human Alpha Globin Cluster during Hematopoiesis
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The mechanism of alpha-globin activation during erythropoiesis
द्वारा: Higgs, D, और अन्य
प्रकाशित: (2007)

A novel deletion causing alpha thalassemia clarifies the importance of the major human alpha globin regulatory element.
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प्रकाशित: (2006)

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द्वारा: Higgs, D, और अन्य
प्रकाशित: (2008)

Analysis of the human alpha-globin gene cluster reveals a highly informative genetic locus.
द्वारा: Higgs, D, और अन्य
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A 16.5 kb deletion in the alpha globin cluster associated with an extremely mild phenotype
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प्रकाशित: (2007)

Long-range regulation of alpha globin gene expression during erythropoiesis.
द्वारा: Higgs, D, और अन्य
प्रकाशित: (2008)

Deletion of the alpha-globin gene cluster as a cause of acquired alpha-thalassemia in myelodysplastic syndrome.
द्वारा: Steensma, D, और अन्य
प्रकाशित: (2004)

A METHOD FOR THE HIGH-RESOLUTION IDENTIFICATION OF ACTIVE CIS ELEMENTS FOR ANY GIVEN GENE AND ITS APPLICATION TO THE HUMAN ALPHA GLOBIN LOCUS
द्वारा: Hughes, J, और अन्य
प्रकाशित: (2009)

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द्वारा: Sharpe, J, और अन्य
प्रकाशित: (1993)

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Identification of mutations in a trans-acting factor with different effects on alpha and beta globin expression.
द्वारा: Viprakasit, V, और अन्य
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Identification of mutations in a trans-acting factor with different effects on alpha and beta globin expression.
द्वारा: Viprakasit, V, और अन्य
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EFFECT OF CIS ACTING POTENTIAL REGULATORS IN THE ß GLOBIN GENE CLUSTER ON THE PRODUCTION OF HBF IN THALASSEMIA PATIENTS
द्वारा: Anita Nadkarni
प्रकाशित: (2013-02-01)

The role of histone deacetylases in repressing alpha-globin gene expression in non-erythroid cells.
द्वारा: Garrick, D, और अन्य
प्रकाशित: (2003)

Does Transcription of Remote alpha-Globin Regulatory Elements Affect Their Function?
द्वारा: Kowalczyk, MS, और अन्य
प्रकाशित: (2009)

Expression of the human alpha-globin cluster in the absence of the major regulatory element Mcs-R2
द्वारा: Badat, M, और अन्य
प्रकाशित: (2018)

Identification of a conserved erythroid specific domain of histone acetylation across the alpha-globin gene cluster.
द्वारा: Anguita, E, और अन्य
प्रकाशित: (2001)

A revised model for promoter competition based on multi-way chromatin interactions at the α-globin locus
द्वारा: Oudelaar, A, और अन्य
प्रकाशित: (2019)

Activation of the alpha-globin gene expression correlates with dramatic upregulation of nearby non-globin genes and changes in local and large-scale chromatin spatial structure
द्वारा: Sergey V. Ulianov, और अन्य
प्रकाशित: (2017-07-01)

Independent recombination events between the duplicated human alpha globin genes; implications for their concerted evolution.
द्वारा: Higgs, D, और अन्य
प्रकाशित: (1984)

Understanding alpha-globin gene regulation: Aiming to improve the management of thalassemia.
द्वारा: Higgs, D, और अन्य
प्रकाशित: (2005)

The structure of a human alpha-globin pseudogene and its relationship to alpha-globin gene duplication.
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प्रकाशित: (1980)

Alpha Thalassemia in Istanbul: Distribution of Deletions in Alpha-globin Gene Cluster
द्वारा: Fatma Nihal Öztürk
प्रकाशित: (2024-06-01)

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प्रकाशित: (1990)