Structure of three tandem filamin domains reveals auto-inhibition of ligand binding.

Structure of three tandem filamin domains reveals auto-inhibition of ligand binding.

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Human filamins are large actin-crosslinking proteins composed of an N-terminal actin-binding domain followed by 24 Ig-like domains (IgFLNs), which interact with numerous transmembrane receptors and cytosolic signaling proteins. Here we report the 2.5 A resolution structure of a three-domain fragment...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Lad, Y, Kiema, T, Jiang, P, Pentikäinen, O, Coles, C, Campbell, I, Calderwood, D, Ylänne, J
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	2007

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