Purification and activity determination of ADAMTS-4 and ADAMTS-5 and their domain deleted mutants

Purification and activity determination of ADAMTS-4 and ADAMTS-5 and their domain deleted mutants

AA disintegrin-like and metalloproteinase with thrombospondin type-1 motifs-4 (ADAMTS-4) and ADAMTS-5 are zinc-dependent metalloproteinases that are involved in the maintenance of cartilage extracellular matrix (ECM) and are currently considered the major aggrecanases in the development of osteoarth...

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Bibliografische gegevens
Hoofdauteurs:	Fowkes, MM, Lim, NH
Andere auteurs:	Apte, SS
Formaat:	Book section
Taal:	English
Gepubliceerd in:	Humana Press 2019

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Development of selective ADAMTS-5 peptide substrates to monitor proteinase activity
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Functional differences of the catalytic and non-catalytic domains in human ADAMTS-4 and ADAMTS-5 in aggrecanolytic activity.
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Proteolytic activities of human ADAMTS-5: comparative studies with ADAMTS-4.
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Reactive-site mutants of N-TIMP-3 that selectively inhibit ADAMTS-4 and ADAMTS-5: biological and structural implications.
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The C-terminal domains of ADAMTS-4 and ADAMTS-5 promote association with N-TIMP-3.
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ADAMTS4 and ADAMTS5 are upregulated early in the DMM model of murine OA
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Engineering and expression of ADAMTS-4 and ADAMTS-5, proteolytic enzymes involved in osteoarthritis progression
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Serum Level of ADAMTS4 and ADAMTS8 in Patients with Psoriatic Arthritis
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ADAMTS2 and ADAMTS14 can substitute for ADAMTS3 in adults for pro-VEGFC activation and lymphatic homeostasis
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The ADAMTS/Fibrillin Connection: Insights into the Biological Functions of ADAMTS10 and ADAMTS17 and Their Respective Sister Proteases
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Cleavage of Fibulin-2 by the aggrecanases ADAMTS-4 and ADAMTS-5 contributes to the tumorigenic potential of breast cancer cells
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Genetic variants in ADAMTS13 as well as smoking are major determinants of plasma ADAMTS13 levels
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ADAMTS-5: The story so far
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Investigation of the endocytic pathway of ADAMTS-4
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Low density lipoprotein receptor-related protein 1 (LRP1)-mediated endocytic clearance of a disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS-4): functional differences of non-catalytic domains of ADAMTS-4 and ADAMTS-5 in LRP1 binding.
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Multiple domains of ADAMTS13 are targeted by autoantibodies against ADAMTS13 in patients with acquired idiopathic thrombotic thrombocytopenic purpura
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Regulation of ADAMTS Proteases
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Acquired thrombotic thrombocytopenic purpura: ADAMTS13 activity, anti-ADAMTS13 autoantibodies and risk of recurrent disease
door: Bernhard Lämmle, et al.
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Thrombotic thrombocytopenic purpura with decreased level of ADAMTS-13 activity and increased level of ADAMTS-13 inhibitor in an adolescent
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Disappearing acts of ADAMTS13
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Determination of ADAMTS13 and Its Clinical Significance for ADAMTS13 Supplementation Therapy to Improve the Survival of Patients with Decompensated Liver Cirrhosis
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Functional role of ADAMTS5 in adiposity and metabolic health.
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Exosite inhibition of ADAMTS-5 by a glycoconjugated arylsulfonamide
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Ocular pulse amplitude (OPA) in canine ADAMTS10-open-angle glaucoma (ADAMTS10-OAG)
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ADAMTS13 Deficiency Worsens Colitis and Exogenous ADAMTS13 Administration Decreases Colitis Severity in Mice
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Evidence for a role of anti-ADAMTS13 autoantibodies despite normal ADAMTS13 activity in recurrent thrombotic thrombocytopenic purpura
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Altered proteolytic activities of ADAMTS-4 expressed by C-terminal processing.
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Interleukin-1α induces ADAMTS-mediated aggrecanolysis in the bovine meniscus: evidence for a primary role of ADAMTS-4 in meniscus destruction
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Gepubliceerd in: (2012)

ADAMTS proteases in cardiovascular physiology and disease
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Gepubliceerd in: (2020-12-01)

ADAMTS13 and anti-ADAMTS13 antibodies as markers for recurrence of acquired thrombotic thrombocytopenic purpura during remission
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In vivo N-Terminomics Highlights Novel Functions of ADAMTS2 and ADAMTS14 in Skin Collagen Matrix Building
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Assay for ADAMTS-13 Activity with Flow Cytometric Readout
door: Jens Müller, et al.
Gepubliceerd in: (2022-08-01)

Genetic variation of aggrecanase-2 (ADAMTS5) in susceptibility to osteoarthritis
door: Xindie Zhou, et al.
Gepubliceerd in: (2019-01-01)

The first deletion mutation in the TSP1-6 repeat domain of ADAMTS13 in a family with inherited thrombotic thrombocytopenic purpura
door: Roberta Palla, et al.
Gepubliceerd in: (2009-02-01)

ADAMTS7, a target in atherosclerosis, cooperates with its homolog ADAMTS12 to protect against myxomatous valve degeneration
door: Timothy J. Mead, et al.
Gepubliceerd in: (2025-03-01)

Hemoglobin stimulates the expression of ADAMTS-5 and ADAMTS-9 by synovial cells: a possible cause of articular cartilage damage after intra-articular hemorrhage
door: Takuya Tajima, et al.
Gepubliceerd in: (2017-11-01)

The Function and Roles of ADAMTS-7 in Inflammatory Diseases
door: Yuying Zhang, et al.
Gepubliceerd in: (2015-01-01)

The Mechanism and Role of ADAMTS Protein Family in Osteoarthritis
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Expression and prognosis of ADAMTS18 in different tumors
door: Wenfei Guo, et al.
Gepubliceerd in: (2024-02-01)