Targeting the MYCN-MDM2 pathways for cancer therapy: Are they druggable?

Targeting oncogenes and their interactive partners is an effective approach to developing novel targeted therapies for cancer and other chronic diseases. We and others have long suggested the MDM2 oncogene being an excellent target for cancer therapy, based on its p53-dependent and -independent onco...

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Bibliographic Details
Main Authors: Wei Wang, Yi Du, Sayantap Datta, Josef F. Fowler, Hannah T. Sang, Najah Albadari, Wei Li, Jennifer Foster, Ruiwen Zhang
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2025-03-01
Series:Genes and Diseases
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2352304223004397