Stochastic Model of the Adaptive Immune Response Predicts Disease Severity and Captures Enhanced Cross-Reactivity in Natural Dengue Infections
The dengue virus circulates as four distinct serotypes, where a single serotype infection is typically asymptomatic and leads to acquired immunity against that serotype. However, the developed immunity to one serotype is thought to underlie the severe manifestation of the disease observed in subsequ...
Main Authors: | Hung D. Nguyen, Sidhartha Chaudhury, Adam T. Waickman, Heather Friberg, Jeffrey R. Currier, Anders Wallqvist |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2021-08-01
|
Series: | Frontiers in Immunology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.696755/full |
Similar Items
-
A stochastic B cell affinity maturation model to characterize mechanisms of protection for tetravalent dengue vaccine constructs
by: Venkat R. Pannala, et al.
Published: (2023-07-01) -
Host immunity and vaccine development against Dengue virus
by: Enhao Ma, et al.
Published: (2022-03-01) -
Assessing the Diversity and Stability of Cellular Immunity Generated in Response to the Candidate Live-Attenuated Dengue Virus Vaccine TAK-003
by: Adam T. Waickman, et al.
Published: (2019-07-01) -
The role of the immune response in the etiopathogenesis of endometriosis
by: Catalina Diana Stanica, et al.
Published: (2021-03-01) -
Immunosuppressive Effects of Trifluralin on NMRI Mice
by: M Abtahi Froushani, et al.
Published: (2015-08-01)