Biodistribution and toxicity assessment of methoxyphenyl phosphonium carbosilane dendrimers in 2D and 3D cell cultures of human cancer cells and zebrafish embryos

Abstract The consideration of human and environmental exposure to dendrimers, including cytotoxicity, acute toxicity, and cell and tissue accumulation, is essential due to their significant potential for various biomedical applications. This study aimed to evaluate the biodistribution and toxicity o...

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Bibliographic Details
Main Authors: Zuzana Žmudová, Zuzana Šanderová, Michaela Liegertová, Stanislav Vinopal, Regina Herma, Luděk Sušický, Monika Müllerová, Tomáš Strašák, Jan Malý
Format: Article
Language:English
Published: Nature Portfolio 2023-09-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-42850-3