Progranulin Levels in Plasma and Cerebrospinal Fluid in Granulin Mutation Carriers
Background: Pathogenic mutations in the granulin gene (GRN) are causative in 5-10% of patients with frontotemporal dementia (FTD), mostly leading to reduced progranulin protein (PGRN) levels. Upcoming therapeutic trials focus on enhancing PGRN levels. Methods: Fluctuations in plasma PGRN (n = 41) an...
Main Authors: | Lieke H.H. Meeter, Holger Patzke, Gordon Loewen, Elise G.P. Dopper, Yolande A.L. Pijnenburg, Rick van Minkelen, John C. van Swieten |
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Format: | Article |
Language: | English |
Published: |
Karger Publishers
2016-07-01
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Series: | Dementia and Geriatric Cognitive Disorders Extra |
Subjects: | |
Online Access: | http://www.karger.com/Article/FullText/447738 |
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