Potential biomarkers and targets of mitochondrial dynamics
Abstract Mitochondrial dysfunction contributes to the imbalance of cellular homeostasis and the development of diseases, which is regulated by mitochondria‐associated factors. The present review aims to explore the process of the mitochondrial quality control system as a new source of the potential...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-08-01
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| Series: | Clinical and Translational Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ctm2.529 |
| _version_ | 1828929606095208448 |
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| author | Liyang Li Ruixue Qi Linlin Zhang Yuexin Yu Jiayun Hou Yutong Gu Dongli Song Xiangdong Wang |
| author_facet | Liyang Li Ruixue Qi Linlin Zhang Yuexin Yu Jiayun Hou Yutong Gu Dongli Song Xiangdong Wang |
| author_sort | Liyang Li |
| collection | DOAJ |
| description | Abstract Mitochondrial dysfunction contributes to the imbalance of cellular homeostasis and the development of diseases, which is regulated by mitochondria‐associated factors. The present review aims to explore the process of the mitochondrial quality control system as a new source of the potential diagnostic biomarkers and/or therapeutic targets for diseases, including mitophagy, mitochondrial dynamics, interactions between mitochondria and other organelles (lipid droplets, endoplasmic reticulum, endosomes, and lysosomes), as well as the regulation and posttranscriptional modifications of mitochondrial DNA/RNA (mtDNA/mtRNA). The direct and indirect influencing factors were especially illustrated in understanding the interactions among regulators of mitochondrial dynamics. In addition, mtDNA/mtRNAs and proteomic profiles of mitochondria in various lung diseases were also discussed as an example. Thus, alternations of mitochondria‐associated regulators can be a new category of biomarkers and targets for disease diagnosis and therapy. |
| first_indexed | 2024-12-14T00:21:38Z |
| format | Article |
| id | doaj.art-bfff6c3d0d1540368da6261f2b0b5d80 |
| institution | Directory Open Access Journal |
| issn | 2001-1326 |
| language | English |
| last_indexed | 2024-12-14T00:21:38Z |
| publishDate | 2021-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Translational Medicine |
| spelling | doaj.art-bfff6c3d0d1540368da6261f2b0b5d802022-12-21T23:25:12ZengWileyClinical and Translational Medicine2001-13262021-08-01118n/an/a10.1002/ctm2.529Potential biomarkers and targets of mitochondrial dynamicsLiyang Li0Ruixue Qi1Linlin Zhang2Yuexin Yu3Jiayun Hou4Yutong Gu5Dongli Song6Xiangdong Wang7Zhongshan Hospital, Department of Pulmonary and Critical Care Medicine, Shanghai Institute of Clinical Bioinformatics Shanghai Engineering Research for AI Technology for Cardiopulmonary Diseases Shanghai ChinaJinshan Hospital Centre for Tumor Diagnosis and Therapy Fudan University Shanghai Medical College Shanghai ChinaZhongshan Hospital, Department of Pulmonary and Critical Care Medicine, Shanghai Institute of Clinical Bioinformatics Shanghai Engineering Research for AI Technology for Cardiopulmonary Diseases Shanghai ChinaZhongshan Hospital, Department of Pulmonary and Critical Care Medicine, Shanghai Institute of Clinical Bioinformatics Shanghai Engineering Research for AI Technology for Cardiopulmonary Diseases Shanghai ChinaZhongshan Hospital, Department of Pulmonary and Critical Care Medicine, Shanghai Institute of Clinical Bioinformatics Shanghai Engineering Research for AI Technology for Cardiopulmonary Diseases Shanghai ChinaZhongshan Hospital, Department of Pulmonary and Critical Care Medicine, Shanghai Institute of Clinical Bioinformatics Shanghai Engineering Research for AI Technology for Cardiopulmonary Diseases Shanghai ChinaZhongshan Hospital, Department of Pulmonary and Critical Care Medicine, Shanghai Institute of Clinical Bioinformatics Shanghai Engineering Research for AI Technology for Cardiopulmonary Diseases Shanghai ChinaZhongshan Hospital, Department of Pulmonary and Critical Care Medicine, Shanghai Institute of Clinical Bioinformatics Shanghai Engineering Research for AI Technology for Cardiopulmonary Diseases Shanghai ChinaAbstract Mitochondrial dysfunction contributes to the imbalance of cellular homeostasis and the development of diseases, which is regulated by mitochondria‐associated factors. The present review aims to explore the process of the mitochondrial quality control system as a new source of the potential diagnostic biomarkers and/or therapeutic targets for diseases, including mitophagy, mitochondrial dynamics, interactions between mitochondria and other organelles (lipid droplets, endoplasmic reticulum, endosomes, and lysosomes), as well as the regulation and posttranscriptional modifications of mitochondrial DNA/RNA (mtDNA/mtRNA). The direct and indirect influencing factors were especially illustrated in understanding the interactions among regulators of mitochondrial dynamics. In addition, mtDNA/mtRNAs and proteomic profiles of mitochondria in various lung diseases were also discussed as an example. Thus, alternations of mitochondria‐associated regulators can be a new category of biomarkers and targets for disease diagnosis and therapy.https://doi.org/10.1002/ctm2.529lung diseasesmitochondriamitochondrial dynamicsmtDNA |
| spellingShingle | Liyang Li Ruixue Qi Linlin Zhang Yuexin Yu Jiayun Hou Yutong Gu Dongli Song Xiangdong Wang Potential biomarkers and targets of mitochondrial dynamics Clinical and Translational Medicine lung diseases mitochondria mitochondrial dynamics mtDNA |
| title | Potential biomarkers and targets of mitochondrial dynamics |
| title_full | Potential biomarkers and targets of mitochondrial dynamics |
| title_fullStr | Potential biomarkers and targets of mitochondrial dynamics |
| title_full_unstemmed | Potential biomarkers and targets of mitochondrial dynamics |
| title_short | Potential biomarkers and targets of mitochondrial dynamics |
| title_sort | potential biomarkers and targets of mitochondrial dynamics |
| topic | lung diseases mitochondria mitochondrial dynamics mtDNA |
| url | https://doi.org/10.1002/ctm2.529 |
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