Klebsiella pneumoniae K2 capsular polysaccharide degradation by a bacteriophage depolymerase does not require trimer formation

Klebsiella pneumoniae K2 capsular polysaccharide degradation by a bacteriophage depolymerase does not require trimer formation

ABSTRACT K2-capsular Klebsiella pneumoniae is a hypervirulent pathogen that causes fatal infections. Here, we describe a phage tailspike protein, named K2-2, that specifically depolymerizes the K2 capsular polysaccharide (CPS) of K. pneumoniae into tetrasaccharide repeating units. Nearly half of the...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид: Ting-Juan Ye, Kit-Man Fung, I-Ming Lee, Tzu-Ping Ko, Chia-Yi Lin, Chia-Ling Wong, I-Fan Tu, Tzu-Yin Huang, Feng-Ling Yang, Yu-Pei Chang, Jin-Town Wang, Tzu-Lung Lin, Kai-Fa Huang, Shih-Hsiung Wu
Формат: Өгүүллэг
Хэл сонгох:English
Хэвлэсэн: American Society for Microbiology 2024-03-01
Цуврал:mBio
Нөхцлүүд:
Klebsiella pneumonia
bacteriophage
tailspike protein
O-acetylation
intersubunit carbohydrate-binding site
Онлайн хандалт:https://journals.asm.org/doi/10.1128/mbio.03519-23

Интернэт

https://journals.asm.org/doi/10.1128/mbio.03519-23

Ижил төстэй зүйлс