MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors

MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors

There is increasing evidence that oncogenic transformation modifies the metabolic program of cells. A common alteration is the upregulation of glycolysis, and efforts to target glycolytic enzymes for anticancer therapy are under way. Here, we performed a genome-wide haploid genetic screen to identif...

Popoln opis

Bibliografske podrobnosti
Main Authors: Birsoy, Kivanc, Wang, Tim, Possemato, Richard, Koch, Catherine E., Chen, Walter W., Hutchins, Amanda W., Gultekin, Yetis, Carette, Jan E., Brummelkamp, Thijn R., Clish, Clary, Yilmaz, Omer, Peterson, Timothy Richard, Sabatini, David
Drugi avtorji: Massachusetts Institute of Technology. Department of Biology
Format: Article
Jezik:en_US
Izdano: Nature Publishing Group 2013
Online dostop:http://hdl.handle.net/1721.1/79435
https://orcid.org/0000-0002-4227-5163
https://orcid.org/0000-0002-2401-0030
https://orcid.org/0000-0002-7043-5013
https://orcid.org/0000-0002-7577-4612
https://orcid.org/0000-0002-1446-7256
https://orcid.org/0000-0002-1751-7327

Internet

http://hdl.handle.net/1721.1/79435
https://orcid.org/0000-0002-4227-5163
https://orcid.org/0000-0002-2401-0030
https://orcid.org/0000-0002-7043-5013
https://orcid.org/0000-0002-7577-4612
https://orcid.org/0000-0002-1446-7256
https://orcid.org/0000-0002-1751-7327

Podobne knjige/članki