Determining the influence of structure on hybridization using oligonucleotide arrays.

We have studied the effects of structure on nucleic acid heteroduplex formation by analyzing hybridization of tRNAphe to a complete set of complementary oligonucleotides, ranging from single nucleotides to dodecanucleotides. The analysis points to features in tRNA that determine heteroduplex yield....

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Detalhes bibliográficos
Principais autores: Mir, K, Southern, E
Formato: Journal article
Idioma:English
Publicado em: 1999