Enhanced discriminative aversive learning and amygdala responsivity in 5-HT transporter mutant mice

Enhanced discriminative aversive learning and amygdala responsivity in 5-HT transporter mutant mice

Näytä muut versiot (1)

Genetic variation in the human serotonin transporter (5-HTT) has been linked to altered fear learning but the data are inconsistent and the mechanism is unclear. The present study investigated conditioned aversive learning in 5-HTT knockout (KO) mice while simultaneously recording neural network act...

Bibliografiset tiedot
Päätekijät:	Lima, J, Sharp, T, Bannerman, D, McHugh, S
Aineistotyyppi:	Journal article
Kieli:	English
Julkaistu:	Nature 2019

Samankaltaisia teoksia

Enhanced discriminative aversive learning and amygdala responsivity in 5-HT transporter mutant mice
Tekijä: Lima, J, et al.
Julkaistu: (2019)

Aversive prediction error signals in the amygdala.
Tekijä: McHugh, S, et al.
Julkaistu: (2014)

SERT and uncertainty: serotonin transporter expression influences information processing biases for ambiguous aversive cues in mice
Tekijä: McHugh, SB, et al.
Julkaistu: (2015)

Control of amygdala circuits by 5-HT neurons via 5-HT and glutamate co-transmission
Tekijä: Sengupta, A, et al.
Julkaistu: (2017)

Serotonin, amygdala and fear: Assembling the puzzle
Tekijä: Bocchio, M, et al.
Julkaistu: (2016)

Variation in serotonin transporter expression modulates fear-evoked hemodynamic responses and theta-frequency neuronal oscillations in the amygdala.
Tekijä: Barkus, C, et al.
Julkaistu: (2014)

Hemodynamic responses in amygdala and hippocampus distinguish between aversive and neutral cues during Pavlovian fear conditioning in behaving rats.
Tekijä: McHugh, S, et al.
Julkaistu: (2013)

Human 5-HT transporter availability predicts amygdala reactivity in vivo.
Tekijä: Rhodes, R, et al.
Julkaistu: (2007)

Increased serotonin transporter expression reduces fear and recruitment of parvalbumin interneurons of the amygdala
Tekijä: Bocchio, M, et al.
Julkaistu: (2015)

Mice that over-express the 5-HT transporter show evidence of region-specific changes in 5-HT neurotransmission
Tekijä: Jennings, K, et al.
Julkaistu: (2004)

Variation in serotonin transporter expression modulates fear-evoked hemodynamic responses and theta-frequency neuronal oscillations in the amygdala
Tekijä: Barkus, C, et al.
Julkaistu: (2014)

Hemodynamic responses in amygdala and hippocampus distinguish between aversive and neutral cues during Pavlovian fear conditioning in behaving rats
Tekijä: Mchugh, S, et al.
Julkaistu: (2013)

Mice over-expressing the 5-HT transporter show evidence of increased central 5-HT2A function
Tekijä: Jennings, K, et al.
Julkaistu: (2003)

Neurobiological effects of increased expression of the 5-HT transporter
Tekijä: Sharp, T, et al.
Julkaistu: (2008)

Analysis of brain 5-HT function in transgenic mice overexpressing the 5-HT transporter
Tekijä: Jennings, K
Julkaistu: (2005)

Medial amygdala arginine vasopressin neurons regulate innate aversion to cat odors in male mice
Tekijä: Tong, Wen Han, et al.
Julkaistu: (2022)

NEUROBIOLOGICAL EFFECTS OF ALTERED 5-HT TRANSPORTER EXPRESSION: IMPLICATIONS FOR DEPRESSION AND ANXIETY
Tekijä: Sharp, T, et al.
Julkaistu: (2010)

Amygdala and ventral hippocampus contribute differentially to mechanisms of fear and anxiety.
Tekijä: McHugh, S, et al.
Julkaistu: (2004)

Expression of 5-HT receptors and the 5-HT transporter in rat brain after electroconvulsive shock.
Tekijä: Burnet, P, et al.
Julkaistu: (1999)

Non-linear relationship between 5-HT transporter gene expression and frequency sensitivity of 5-HT signals.
Tekijä: Jennings, K, et al.
Julkaistu: (2010)

Fast scan cyclic voltammetry evidence that 5-HT transporter overexpression impairs the function of 5-HT nerve terminals
Tekijä: Jennings, K, et al.
Julkaistu: (2008)

Polymorphism of the 5-HT transporter and response to antidepressants: randomised controlled trial.
Tekijä: Lewis, G, et al.
Julkaistu: (2011)

Evidence that genetic variation in 5-HT transporter expression is linked to changes in 5-HT2A receptor function.
Tekijä: Jennings, K, et al.
Julkaistu: (2008)

Mice overexpressing the 5-hydroxytryptamine transporter show no alterations in feeding behaviour and increased non-feeding responses to fenfluramine.
Tekijä: Pringle, A, et al.
Julkaistu: (2008)

Simultaneous blockade of 5-HT1A/B receptors and 5-HT transporters results in acute increases in extracellular 5-HT in both rats and guinea pigs: in vivo characterization of the novel 5-HT1A/B receptor antagonist/5-HT transport inhibitor SB-649915-B.
Tekijä: Hughes, Z, et al.
Julkaistu: (2007)

ENDOCRINOLOGIC RESPONSES TO 5-HT
Tekijä: Cowen, P, et al.
Julkaistu: (1990)

Increased expression of the 5-HT transporter confers a low-anxiety phenotype linked to decreased 5-HT transmission.
Tekijä: Jennings, K, et al.
Julkaistu: (2006)

Evidence that 5-HT2 receptor agonist induced inhibtion of 5-HT cell firing is mediated by central and not peripheral 5-HT2 receptors
Tekijä: Boothman, L, et al.
Julkaistu: (2003)

The effect of lithium on 5-HT-mediated neuroendocrine responses and platelet 5-HT receptors.
Tekijä: Glue, P, et al.
Julkaistu: (1986)

Activation of 5-HT(6) receptors facilitates attentional set shifting.
Tekijä: Burnham, K, et al.
Julkaistu: (2010)

5-HT and depression: is the glass half-full?
Tekijä: Sharp, T, et al.
Julkaistu: (2011)

A possible role for 5-HT2C receptors in postsynaptic feedback regulation of 5 HT neurones
Tekijä: Raley, J, et al.
Julkaistu: (2006)

Effects of the 5-HT(4) receptor agonist RS67333 and paroxetine on hippocampal extracellular 5-HT levels.
Tekijä: Licht, C, et al.
Julkaistu: (2010)

Emotional Processing, Amygdala Activation and the Serotonin Transporter Genotype (5HTTLPR)
Tekijä: Murphy, SE, et al.
Julkaistu: (2009)

Evidence that central 5-HT2A and 5-HT2B/C receptors regulate 5-HT cell firing in the dorsal raphe nucleus of the anaesthetised rat.
Tekijä: Boothman, L, et al.
Julkaistu: (2003)

Rebound activation of 5-HT neurons following SSRI discontinuation
Tekijä: Collins, HM, et al.
Julkaistu: (2024)

Genetic variation in 5-hydroxytryptamine transporter expression causes adaptive changes in 5-HT₄ receptor levels.
Tekijä: Jennings, K, et al.
Julkaistu: (2012)

Role of the amygdala in picture discrimination learning with 24-h intertrial intervals.
Tekijä: Gaffan, D
Julkaistu: (1994)

Consequences of changes in BDNF levels on serotonin neurotransmission, 5-HT transporter expression and function: studies in adult mice hippocampus.
Tekijä: Deltheil, T, et al.
Julkaistu: (2008)

Clomipramine enhances the cortisol response to 5-HTP: implications for the therapeutic role of 5-HT2 receptors.
Tekijä: Sargent, P, et al.
Julkaistu: (1998)