A human protein hydroxylase that accepts D-residues

A human protein hydroxylase that accepts D-residues

Factor inhibiting hypoxia-inducible factor (FIH) is a 2-oxoglutarate-dependent protein hydroxylase that catalyses C3 hydroxylations of protein residues. We report FIH can accept (D)- and (L)-residues for hydroxylation. The substrate selectivity of FIH differs for (D) and (L) epimers, e.g., (D)- but...

ver descrição completa

Detalhes bibliográficos
Main Authors: Choi, H, Hardy, AP, Leissing, TM, Chowdhury, R, Nakashima, Y, Ge, W, Markoulides, M, Scotti, JS, Gerken, PA, Thorbjornsrud, H, Kang, D, Hong, S, Lee, J, McDonough, MA, Park, H, Schofield, CJ
Formato: Journal article
Idioma:English
Publicado em: Springer Nature 2020
Assuntos:
Biocatalysis
X-ray crystallography

Registos relacionados

Registos relacionados