Inhibiting TLR7 Expression in the Retinal Pigment Epithelium Suppresses Experimental Autoimmune Uveitis

Inhibiting TLR7 Expression in the Retinal Pigment Epithelium Suppresses Experimental Autoimmune Uveitis

Experimental autoimmune uveitis (EAU), a model of human uveitis, is an organ-specific, T cell-mediated autoimmune disease. Autoreactive T cells can penetrate the blood-retinal barrier, which is a physical defense composed of tight junction-linked retinal pigment epithelial (RPE) cells. RPE cells ser...

Full description

Bibliographic Details
Main Authors:	Sheng-Min Lo, Yih-Shiou Hwang, Chao-Lin Liu, Chia-Ning Shen, Wei-Hsin Hong, Wei-Cheng Yang, Meng-Hua Lee, Chia-Rui Shen
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-01-01
Series:	Frontiers in Immunology
Subjects:	autoimmune uveitis barrier function EAU IL-17 RPE TLR7
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2021.736261/full

Similar Items

Interleukin-4 Supports the Suppressive Immune Responses Elicited by Regulatory T Cells
by: Wei-Cheng Yang, et al.
Published: (2017-11-01)

Cytomegalovirus Uveitis: Taiwan expert consensus
by: Wei-Yu Chiang, et al.
Published: (2023-08-01)

Interleukin 35-Producing Exosomes Suppress Neuroinflammation and Autoimmune Uveitis
by: Minkyung Kang, et al.
Published: (2020-05-01)

Ketogenic diet modulates immune cell transcriptional landscape and ameliorates experimental autoimmune uveitis in mice
by: Runping Duan, et al.
Published: (2024-12-01)

Parental Uveitis Influences Offspring With an Increased Susceptibility to the Experimental Autoimmune Uveitis
by: Guangnian Yin, et al.
Published: (2020-06-01)

STAT3-Specific Single Domain Nanobody Inhibits Expansion of Pathogenic Th17 Responses and Suppresses Uveitis in Mice
by: Evaristus C. Mbanefo, et al.
Published: (2021-09-01)

High salt diet alleviates disease severity in native experimental autoimmune uveitis
by: Naomi Derluyn, et al.
Published: (2024-05-01)

Noncontact Optical Measurement of Aqueous Humor Glucose Levels and Correlation with Serum Glucose Levels in Rabbit
by: Yih-Shiou Hwang, et al.
Published: (2021-10-01)

Bilateral anterior uveitis after immunotherapy for malignant melanoma
by: Chia-Jui Chang, et al.
Published: (2018-01-01)

Use of corticosteroids in non-infectious uveitis – expert consensus in Taiwan
by: Yo-Chen Chang, et al.
Published: (2024-12-01)

Therapeutic Effect of Rapamycin-Loaded Small Extracellular Vesicles Derived from Mesenchymal Stem Cells on Experimental Autoimmune Uveitis
by: Huan Li, et al.
Published: (2022-03-01)

Step-wise diagnostic approach for patients with uveitis - Experts consensus in TaiwanGeneral principles 1:General principles 2:General principles 3:General principles 4:
by: De-Kuang Hwang, et al.
Published: (2022-08-01)

Bevacizumab cured age-related macular degeneration (AMD) via down-regulate TLR2 pathway
by: Wang Zhi, et al.
Published: (2014-05-01)

Intraocular DHODH-inhibitor PP-001 suppresses relapsing experimental uveitis and cytokine production of human lymphocytes, but not of RPE cells
by: Maria Diedrichs-Möhring, et al.
Published: (2018-02-01)

Prevalence of uveitis in syphilis patients in Taiwan
by: Chia-Yun Chen, et al.
Published: (2024-12-01)

Taiwan ocular inflammation society consensus recommendations for the management of juvenile idiopathic arthritis-associated uveitis
by: Wei-Dar Chen, et al.
Published: (2024-12-01)

Immune-Mediated Retinal Vasculitis in Posterior Uveitis and Experimental Models: The Leukotriene (LT)B4-VEGF Axis
by: Malihe Eskandarpour, et al.
Published: (2021-02-01)

Uveítis intermedia: Experiencias terapéuticas Intermediate uveitis: Therapeutic experiences
by: Sandra M. Borges Pérez, et al.
Published: (2001-12-01)

Clinical Manifestations and Outcomes of Tubercular Uveitis in Taiwan—A Ten-Year Multicenter Retrospective Study
by: Chun-Ju Lin, et al.
Published: (2022-03-01)

Kinetic changes in microglia-related retinal transcripts in experimental autoimmune uveoretinitis (EAU) of B10.RIII mice
by: Maren Kasper, et al.
Published: (2025-02-01)

The use of sodium-glucose cotransporter 2 inhibitors and the incidence of uveitis in type 2 diabetes: a population-based cohort study
by: Jui-Fu Chung, et al.
Published: (2024-02-01)

Lo mejor del año en uveítis 2017 Best of 2017 in uveitis
by: Clara Martínez-Rubio, et al.
Published: (2018-01-01)

Role of Epithelial-Mesenchymal Transition in Retinal Pigment Epithelium Dysfunction
by: Mi Zhou, et al.
Published: (2020-06-01)

Uveitis after COVID-19 Vaccination
by: Je Hyung Hwang
Published: (2022-03-01)

Comparison of Sociodemographic Features Between Behçet Uveitis and Other Non-infectious Uveitis
by: F. Nilüfer Yalçındağ, et al.
Published: (2021-08-01)

A Novel Tree Shrew Model of Chronic Experimental Autoimmune Uveitis and Its Disruptive Application
by: Kaijiao Hu, et al.
Published: (2022-05-01)

Managing Psoriatic Arthritis With Inflammatory Bowel Disease and/or Uveitis
by: Alfred Yu Ting Chia, et al.
Published: (2021-09-01)

Study in vivo intraocular biocompatibility of in situ gelation hydrogels: poly(2-ethyl oxazoline)-block-poly(ε-caprolactone)-block-poly(2-ethyl oxazoline) copolymer, matrigel and pluronic F127.
by: Yih-Shiou Hwang, et al.
Published: (2013-01-01)

Drug-induced uveitis: A review
by: Manisha Agarwal, et al.
Published: (2020-01-01)

Intraocular Implants for the Treatment of Autoimmune Uveitis
by: Darren J. Lee
Published: (2015-07-01)

La uveítis, comportamiento clínico epidemiológico en Pinar del Río
by: Barbara Taysel Naranjo Valladares, et al.
Published: (2015-04-01)

Medication-induced Uveitis: An Update
by: Kashif M Iqbal, et al.
Published: (2021-01-01)

Clinical features of cases with retinal pigment epithelium aperture
by: Akie Yoshinaga, et al.
Published: (2021-06-01)

Leptospiral uveitis
by: Jency Maria Koshy, et al.
Published: (2014-08-01)

Evolution of Diagnostic Methods for Infectious and Non-Infectious Uveitis. Review
by: E. V. Boyko, et al.
Published: (2022-07-01)

IL-6/IL-12 superfamily of cytokines and regulatory lymphocytes play critical roles in the etiology and suppression of CNS autoimmune diseases
by: Manoj Kumar Yadav, et al.
Published: (2025-03-01)

Pediatric Uveitis
by: Ilknur Tugal-Tutkun
Published: (2011-01-01)

New onset or recurrence of uveitis following COVID-19 infection
by: Hui Feng, et al.
Published: (2024-01-01)

Challenges of Childhood Uveitis
by: Reem Abdwani
Published: (2009-12-01)

Association of SDF-1 and its receptor CXCR4 polymorphisms on the susceptibility of diabetic retinopathy in the Taiwanese population
by: Shu-Yen Peng, et al.
Published: (2023-11-01)