T cell infiltration and upregulation of MHCII in microglia leads to accelerated neuronal loss in an α-synuclein rat model of Parkinson’s disease
Abstract Background Parkinson’s disease (PD) is the second most prevalent movement disorder characterized by up to 80% loss of dopamine (DA) neurons and accumulation of Lewy body deposits composed of α-synuclein (α-syn). Accumulation of α-syn is associated with microglial activation, leading to a pr...
Main Authors: | Meena S. Subbarayan, Charles Hudson, Lauren D. Moss, Kevin R. Nash, Paula C. Bickford |
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Format: | Article |
Language: | English |
Published: |
BMC
2020-08-01
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Series: | Journal of Neuroinflammation |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s12974-020-01911-4 |
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