Impact of airway closure and lung collapse on inhaled nitric oxide effect in acute lung injury: an experimental study

Impact of airway closure and lung collapse on inhaled nitric oxide effect in acute lung injury: an experimental study

Abstract Background Efficacy of inhaled therapy such as Nitric Oxide (iNO) during mechanical ventilation may depend on airway patency. We hypothesized that airway closure and lung collapse, countered by positive end-expiratory pressure (PEEP), influence iNO efficacy. This could support the role of a...

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Bibliographic Details
Main Authors: Mariangela Pellegrini, Mayson L. A. Sousa, Sebastian Dubo, Luca S. Menga, Vanessa Hsing, Martin Post, Laurent J. Brochard
Format: Article
Language:English
Published: SpringerOpen 2024-09-01
Series:Annals of Intensive Care
Subjects:
(3 to 10) nitric oxide
Acute respiratory distress syndrome
Mechanical ventilation
Airway closure
Online Access:https://doi.org/10.1186/s13613-024-01378-z

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