Thermal proteome profiling for interrogating protein interactions
Abstract Thermal proteome profiling (TPP) is based on the principle that, when subjected to heat, proteins denature and become insoluble. Proteins can change their thermal stability upon interactions with small molecules (such as drugs or metabolites), nucleic acids or other proteins, or upon post‐t...
Main Authors: | André Mateus, Nils Kurzawa, Isabelle Becher, Sindhuja Sridharan, Dominic Helm, Frank Stein, Athanasios Typas, Mikhail M Savitski |
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Format: | Article |
Language: | English |
Published: |
Springer Nature
2020-03-01
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Series: | Molecular Systems Biology |
Subjects: | |
Online Access: | https://doi.org/10.15252/msb.20199232 |
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