Effect of pulsatile stretch on unfolded protein response in a new model of the pulmonary hypertensive vascular wall

Effect of pulsatile stretch on unfolded protein response in a new model of the pulmonary hypertensive vascular wall

Persistent pulmonary hypertension of the newborn (PPHN) is characterized by hypoxemia and arterial remodeling. Dynamic stretch and recoil of the arterial wall during pulsation (in normal conduit arteries, stretch 20% above diastolic diameter) maintains homeostasis; a static arterial wall is associat...

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Bibliographic Details
Main Authors: Martha Hinton, Elwasila Eltayeb, Saeid Ghavami, Shyamala Dakshinamurti
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Biochemistry and Biophysics Reports
Subjects:
Pulmonary artery
Pulsatile stretch
ER stress
Unfolded protein response
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580821001746

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