Research Progress on Mechanism of Action of DHODH in Progression of Malignant Tumors

Research Progress on Mechanism of Action of DHODH in Progression of Malignant Tumors

Dihydroorotate dehydrogenase (DHODH) is a flavin-dependent metabolic enzyme that oxidizes dihydroorotate acid to orotic acid in the de novo synthesis pathway of pyrimidine metabolism. DHODH is located in mitochondria, closely related to cellular oxidative phosphorylation, and an important suppressor...

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Bibliographic Details
Main Authors: CHE Xin, HU Zhen, WANG Yonggang, LI Yaoping
Format: Article
Language:zho
Published: Magazine House of Cancer Research on Prevention and Treatment 2024-03-01
Series:Zhongliu Fangzhi Yanjiu
Subjects:
dihydroorotate dehydrogenase
neoplasms
de novo pyrimidine biosynthesis
oxphos
ferroptosis
dhodh inhibitor
Online Access:http://www.zlfzyj.com/en/article/doi/10.3971/j.issn.1000-8578.2024.23.1067

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http://www.zlfzyj.com/en/article/doi/10.3971/j.issn.1000-8578.2024.23.1067

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