Engineering Nanoparticulate Antigens for Enhanced Follicular Accumulation and Immunogenicity
In vaccine design, antigens are often arrayed in a multivalent nanoparticle form, but in vivo mechanisms underlying the enhanced immunity elicited by such vaccines remain poorly understood. In this thesis, we began by examining two model, HIV-immunogen-bearing nanoparticles that displayed an unusual...
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Massachusetts Institute of Technology
2022
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| Online Access: | https://hdl.handle.net/1721.1/138948 https://orcid.org/0000-0002-4056-296X |