Retroactivity attenuation in signaling cascades
It has been shown in an earlier work that impedance-like effects, called retroactivity, are found at the interconnection of biomolecular systems just as they occur in several engineering systems. These effects are particularly relevant in signaling cascades that have several downstream targets. Thes...
| Main Authors: | , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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Institute of Electrical and Electronics Engineers (IEEE)
2013
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| Online Access: | http://hdl.handle.net/1721.1/78349 https://orcid.org/0000-0001-6472-8576 |
| _version_ | 1826201649701453824 |
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| author | Ossareh, Hamid R. Del Vecchio, Domitilla |
| author2 | Massachusetts Institute of Technology. Department of Mechanical Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Mechanical Engineering Ossareh, Hamid R. Del Vecchio, Domitilla |
| author_sort | Ossareh, Hamid R. |
| collection | MIT |
| description | It has been shown in an earlier work that impedance-like effects, called retroactivity, are found at the interconnection of biomolecular systems just as they occur in several engineering systems. These effects are particularly relevant in signaling cascades that have several downstream targets. These cascades have been extensively studied to determine how a stimulus at the top of the cascade is transmitted and amplified as it propagates toward the bottom of the cascade. In principle, because of retroactivity, a perturbation at the bottom of the cascade can propagate upstream. In this paper, we study the extent to which this propagation occurs by analytically finding retroactivity gains at each stage of the cascade. These gains determine whether a perturbation at the bottom of the cascade is amplified or attenuated as it propagates upstream. |
| first_indexed | 2024-09-23T11:54:38Z |
| format | Article |
| id | mit-1721.1/78349 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T11:54:38Z |
| publishDate | 2013 |
| publisher | Institute of Electrical and Electronics Engineers (IEEE) |
| record_format | dspace |
| spelling | mit-1721.1/783492022-10-01T06:53:27Z Retroactivity attenuation in signaling cascades Ossareh, Hamid R. Del Vecchio, Domitilla Massachusetts Institute of Technology. Department of Mechanical Engineering Del Vecchio, Domitilla It has been shown in an earlier work that impedance-like effects, called retroactivity, are found at the interconnection of biomolecular systems just as they occur in several engineering systems. These effects are particularly relevant in signaling cascades that have several downstream targets. These cascades have been extensively studied to determine how a stimulus at the top of the cascade is transmitted and amplified as it propagates toward the bottom of the cascade. In principle, because of retroactivity, a perturbation at the bottom of the cascade can propagate upstream. In this paper, we study the extent to which this propagation occurs by analytically finding retroactivity gains at each stage of the cascade. These gains determine whether a perturbation at the bottom of the cascade is amplified or attenuated as it propagates upstream. United States. Air Force Office of Scientific Research (Grant FA9550-09-1-0211) 2013-04-11T16:26:05Z 2013-04-11T16:26:05Z 2011-12 Article http://purl.org/eprint/type/ConferencePaper 978-1-61284-799-3 978-1-61284-800-6 0743-1546 http://hdl.handle.net/1721.1/78349 Ossareh, Hamid R., and Domitilla Del Vecchio. “Retroactivity Attenuation in Signaling Cascades.” IEEE, 2011. 2220–2226. https://orcid.org/0000-0001-6472-8576 en_US http://dx.doi.org/10.1109/CDC.2011.6160277 Proceedings of the 50th IEEE Conference on Decision and Control and European Control Conference (CDC-ECC), 2011 Creative Commons Attribution-Noncommercial-Share Alike 3.0 http://creativecommons.org/licenses/by-nc-sa/3.0/ application/pdf Institute of Electrical and Electronics Engineers (IEEE) MIT web domain |
| spellingShingle | Ossareh, Hamid R. Del Vecchio, Domitilla Retroactivity attenuation in signaling cascades |
| title | Retroactivity attenuation in signaling cascades |
| title_full | Retroactivity attenuation in signaling cascades |
| title_fullStr | Retroactivity attenuation in signaling cascades |
| title_full_unstemmed | Retroactivity attenuation in signaling cascades |
| title_short | Retroactivity attenuation in signaling cascades |
| title_sort | retroactivity attenuation in signaling cascades |
| url | http://hdl.handle.net/1721.1/78349 https://orcid.org/0000-0001-6472-8576 |
| work_keys_str_mv | AT ossarehhamidr retroactivityattenuationinsignalingcascades AT delvecchiodomitilla retroactivityattenuationinsignalingcascades |