Artemether-lumefantrine treatment of uncomplicated Plasmodium falciparum malaria: A systematic review and meta-analysis of day 7 lumefantrine concentrations and therapeutic response using individual patient data

Artemether-lumefantrine treatment of uncomplicated Plasmodium falciparum malaria: A systematic review and meta-analysis of day 7 lumefantrine concentrations and therapeutic response using individual patient data

Background: Achieving adequate antimalarial drug exposure is essential for curing malaria. Day 7 blood or plasma lumefantrine concentrations provide a simple measure of drug exposure that correlates well with artemether-lumefantrine efficacy. However, the 'therapeutic' day 7 lumefantrine c...

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Main Authors: Ashley, E, Aweeka, F, Barnes, K, Bassat, Q, Borrmann, S, Dahal, P, Davis, T, Deloron, P, Denis, M, Djimde, A, Faucher, J, Genton, B, Guérin, P, Hamed, K, Hodel, E, Huang, L, Jullien, V, Karunajeewa, H, Kiechel, JR, Kofoed, P, Lefèvre, G, Lindegardh, N, Marsh, K, Mårtensson, A, Mayxay, M, McGready, R, Moreira, C, Newton, P, Ngasala, B, Nosten, F, Nsanzabana, C, Parikh, S, Price, R, Ringwald, P, Rombo, L, Schramm, B, Sibley, C, Stepniewska, K, Ursing, J, Vugt, M, White, N, Workman, L
Format: Journal article
Published: BioMed Central 2015

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