Computational Insights into the Structural Dynamics of MDA5 Variants Associated with Aicardi–Goutières Syndrome and Singleton–Merten Syndrome
Melanoma differentiation-associated protein 5 (MDA5) is a crucial RIG-I-like receptor RNA helicase enzyme encoded by <i>IFIH1</i> in humans. Single nucleotide polymorphisms in the <i>IFIH1</i> results in fatal genetic disorders such as Aicardi–Goutières syndrome and Singleton...
Main Authors: | Vijayakumar Gosu, Santanu Sasidharan, Prakash Saudagar, Hak-Kyo Lee, Donghyun Shin |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-08-01
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Series: | Biomolecules |
Subjects: | |
Online Access: | https://www.mdpi.com/2218-273X/11/8/1251 |
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