A Comparison of the Therapeutic Efficacy of Conventional and Modern Oximes Against Supralethal Doses of Highly Toxic Organophosphates in Mice
1. The therapeutic efficacy of various oximes (pralidoxime, obidoxime, methoxime, HI-6, HLö-7, BI-6) against supralethal nerve agent poisoning (soman, sarin, cyclosin) in mice was tested. 2. New oxime BI-6, synthesized in our laboratory, is significantly more efficacious than conventional oximes but...
Glavni avtor: | Jiří Kassa |
---|---|
Format: | Article |
Jezik: | English |
Izdano: |
Karolinum Press
1998-01-01
|
Serija: | Acta Medica |
Teme: | |
Online dostop: | https://actamedica.lfhk.cuni.cz/41/1/0019/ |
Podobne knjige/članki
-
A Comparison of the Potency of the Oxime HLö-7 and Currently Used Oximes (HI-6, Pralidoxime, Obidoxime) to Reactivate Nerve Agent-Inhibited Rat Brain Acetylcholinesterase by in vitro Methods
od: Kamil Kuča, et al.
Izdano: (2005-01-01) -
FDA-Approved Oximes and Their Significance in Medicinal Chemistry
od: Jyothi Dhuguru, et al.
Izdano: (2022-01-01) -
The Experimental Oxime K027—A Promising Protector From Organophosphate Pesticide Poisoning. A Review Comparing K027, K048, Pralidoxime, and Obidoxime
od: Dietrich E. Lorke, et al.
Izdano: (2019-05-01) -
Stability of Multicomponent Antidote Parenteral Formulations for Autoinjectors against Chemical War Agents (Neurotoxics)
od: María José Rodríguez Fernández, et al.
Izdano: (2024-06-01) -
Differential Inhibition of the Brain Acetylcholinesterase Molecular Forms Following Sarin, Soman and VX Intoxication in Laboratory Rats
od: Jiří Bajgar
Izdano: (1997-01-01)