CDR3 loop flexibility contributes to the degeneracy of TCR recognition.

CDR3 loop flexibility contributes to the degeneracy of TCR recognition.

T cell receptor (TCR) binding degeneracy lies at the heart of several physiological and pathological phenomena, yet its structural basis is poorly understood. We determined the crystal structure of a complex involving the BM3.3 TCR and an octapeptide (VSV8) bound to the H-2K(b) major histocompatibil...

Fuld beskrivelse

Bibliografiske detaljer
Main Authors:	Reiser, J, Darnault, C, Grégoire, C, Mosser, T, Mazza, G, Kearney, A, Van Der Merwe, P, Fontecilla-Camps, J, Housset, D, Malissen, B
Format:	Journal article
Sprog:	English
Udgivet:	2003

Lignende værker

Comparative analysis of the CDR loops of antigen receptors
af: Wong, W, et al.
Udgivet: (2019)

The TCR triggering puzzle.
af: Van Der Merwe, P
Udgivet: (2001)

T cell receptor CDR2 beta and CDR3 beta loops collaborate functionally to shape the iNKT cell repertoire.
af: Mallevaey, T, et al.
Udgivet: (2009)

TCR binding to peptide-MHC stabilizes a flexible recognition interface.
af: Willcox, B, et al.
Udgivet: (1999)

ABlooper: fast accurate antibody CDR loop structure prediction with accuracy estimation
af: Abanades, B, et al.
Udgivet: (2022)

The kinetic-segregation model: TCR triggering and beyond.
af: Davis, S, et al.
Udgivet: (2006)

TCR triggering: co-receptor-dependent or -independent?
af: Davis, S, et al.
Udgivet: (2003)

The kinetic-segregation model: TCR triggering and beyond
af: Davis, S, et al.
Udgivet: (2006)

Destructive Reordering of CDR-Coded Lists
af: Steele, Guy L., Jr.
Udgivet: (2004)

Crystal structure of the O(2)-tolerant membrane-bound hydrogenase 1 from Escherichia coli in complex with its cognate cytochrome b.
af: Volbeda, A, et al.
Udgivet: (2013)

How much can a T-cell antigen receptor adapt to structurally distinct antigenic peptides?
af: Mazza, C, et al.
Udgivet: (2007)

TCR triggering: Co-receptor-dependent or -independent? [2] (multiple letters)
af: Davis, S, et al.
Udgivet: (2003)

LIFTING OF MULTIPHASE DEGENERACY BY QUANTUM FLUCTUATIONS
af: Harris, A, et al.
Udgivet: (1995)

Boundary degeneracy of topological order
af: Wen, Xiao-Gang, et al.
Udgivet: (2015)

Shimura subgroups and degeneracy maps
af: Ling, San
Udgivet: (2013)

Effective theory of quadratic degeneracies
af: Soljačić, Marin, et al.
Udgivet: (2013)

X-ray structural, functional and computational studies of the O2-sensitive E. coli hydrogenase-1 C19G variant reveal an unusual [4Fe–4S] cluster
af: Volbeda, A, et al.
Udgivet: (2018)

Exploring degeneracies in modified gravity with weak lensing
af: Leonard, C, et al.
Udgivet: (2015)

Cyclic phases at an n-fold degeneracy
af: Manolopoulos, D, et al.
Udgivet: (1999)

Hyperbolic conservation laws with umbilic degeneracy
af: Chen, G, et al.
Udgivet: (2001)

Resolution of degeneracy in Merton's portfolio problem
af: Pun, Chi Seng, et al.
Udgivet: (2018)

Ligand detection and discrimination by spatial relocalization: A kinase-phosphatase segregation model of TCR activation.
af: Burroughs, N, et al.
Udgivet: (2006)

CD45 ectodomain controls interaction with GEMs and Lck activity for optimal TCR signaling.
af: Irles, C, et al.
Udgivet: (2003)

Length-independent structural similarities enrich the antibody CDR canonical class model
af: Nowak, J, et al.
Udgivet: (2016)

X-ray crystallographic and computational studies of the O2-tolerant [NiFe]-hydrogenase 1 from Escherichia coli.
af: Volbeda, A, et al.
Udgivet: (2012)

Hydrophobic CDR3 residues promote the development of self-reactive T cells
af: Stadinski, Brian D, et al.
Udgivet: (2017)

A Note on Support Vector Machines Degeneracy
af: Rifkin, Ryan, et al.
Udgivet: (2004)

On component groups of Jo(N) and degeneracy maps
af: Ling, San
Udgivet: (2012)

Regularity for solutions of fully nonlinear elliptic equations with nonhomogeneous degeneracy
af: De Filippis, C
Udgivet: (2020)

Selective effects of electrostatic changes in the CD4 CDR-3-like loop on infection by different human immunodeficiency virus type 1 isolates.
af: Signoret, N, et al.
Udgivet: (1996)

T cell cross-reactivity and conformational changes during TCR engagement.
af: Lee, J, et al.
Udgivet: (2004)

Regulation of temporal cytokine production by co-stimulation receptors in TCR-T cells is lost in CAR-T cells
af: Patel, A, et al.
Udgivet: (2024)

CDR1as/miR-7-5p/IGF1R axis contributes to the suppression of cell viability in prostate cancer
af: Kaya Murat, et al.
Udgivet: (2024-11-01)

The application of the Common Design Recommendations (CDR) in assessing restorative green outdoor environments
af: Adnan, Siti Nur Fathirah, et al.
Udgivet: (2015)

On the Control of TCR Phosphorylation.
af: Fernandes, R, et al.
Udgivet: (2012)

A Framework for Quantifying the Degeneracies of Exoplanet Interior Compositions
af: Rogers, Leslie Anne, et al.
Udgivet: (2012)

Gapped Domain Walls, Gapped Boundaries, and Topological Degeneracy
af: Lan, Tian, et al.
Udgivet: (2015)

Function from configurational degeneracy in disordered framework materials
af: Reynolds, EM, et al.
Udgivet: (2020)

Large and exact quantum degeneracy in a skyrmion magnet
af: Douçot, B, et al.
Udgivet: (2016)

Pervasive degeneracy and epistasis in a protein-protein interface
af: Podgornaia, Anna Igorevna
Udgivet: (2015)