Structure of three tandem filamin domains reveals auto-inhibition of ligand binding
Human filamins are large actin-crosslinking proteins composed of an N-terminal actin-binding domain followed by 24 Ig-like domains (IfFLNs), which interact with numerous transmembrane receptors and cytosolic signaling proteins. Here we report the 2.5 Å resolution structure of a three-domain fragment...
| Үндсэн зохиолчид: | , , , , , , , |
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| Бусад зохиолчид: | |
| Формат: | Journal article |
| Хэл сонгох: | English |
| Хэвлэсэн: |
Nature Publishing Group
2007
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| Нөхцлүүд: |