Synthesis, anticancer evaluation, and molecular modeling study of new 2-(phenylamino)pyrazolo[1,5-a]pyrimidine analogues

Synthesis, anticancer evaluation, and molecular modeling study of new 2-(phenylamino)pyrazolo[1,5-a]pyrimidine analogues

The reaction of 3-amino-5-phenylaminopyrazoles 2 with 3-(dimethylamino) acrylonitrile derivatives resulted in a series of substituted pyrazolopyrimidine analogues 4 and 6. The DFT studies of the isolated compounds showed that the frontier molecular orbitals energy gap was close and in the 2.65–2.81 ...

תיאור מלא

מידע ביבליוגרפי
Main Authors:	Omer A. Azher, Aisha Hossan, Rami A. Pashameah, Amerah Alsoliemy, Arwa Alharbi, Turki M. Habeebullah, Nashwa M. El-Metwaly
פורמט:	Article
שפה:	English
יצא לאור:	Elsevier 2023-01-01
סדרה:	Arabian Journal of Chemistry
נושאים:	3-aminopyrazoles Pyrazolopyrimidines Molecular modelling MCF-7 Molecular docking
גישה מקוונת:	http://www.sciencedirect.com/science/article/pii/S1878535222007535

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