Macrophage responses to lipopolysaccharide are modulated by a feedback loop involving prostaglandin E2, dual specificity phosphatase 1 and tristetraprolin

Macrophage responses to lipopolysaccharide are modulated by a feedback loop involving prostaglandin E2, dual specificity phosphatase 1 and tristetraprolin

Abstract In many different cell types, pro-inflammatory agonists induce the expression of cyclooxygenase 2 (COX-2), an enzyme that catalyzes rate-limiting steps in the conversion of arachidonic acid to a variety of lipid signaling molecules, including prostaglandin E2 (PGE2). PGE2 has key roles in m...

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Xehetasun bibliografikoak
Egile Nagusiak: Tina Tang, Thomas E. Scambler, Tim Smallie, Helen E. Cunliffe, Ewan A. Ross, Dalya R. Rosner, John D. O’Neil, Andrew R. Clark
Formatua: Artikulua
Hizkuntza:English
Argitaratua: Nature Portfolio 2017-06-01
Saila:Scientific Reports
Sarrera elektronikoa:https://doi.org/10.1038/s41598-017-04100-1

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