The Self-Assembly Phenomenon of Poloxamers and Its Effect on the Dissolution of a Poorly Soluble Drug from Solid Dispersions Obtained by Solvent Methods

The Self-Assembly Phenomenon of Poloxamers and Its Effect on the Dissolution of a Poorly Soluble Drug from Solid Dispersions Obtained by Solvent Methods

The self-assembly phenomenon of amphiphiles has attracted particular attention in recent years due to its wide range of applications. The formation of nanoassemblies able to solubilize sparingly water-soluble drugs was found to be a strategy to solve the problem of poor solubility of active pharmace...

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Bibliographic Details
Main Authors: Joanna Szafraniec, Agata Antosik, Justyna Knapik-Kowalczuk, Krzysztof Chmiel, Mateusz Kurek, Karolina Gawlak, Joanna Odrobińska, Marian Paluch, Renata Jachowicz
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Pharmaceutics
Subjects:
bicaludamide
poloxamer
evaporation
spray drying
dissolution enhancement
nanoaggregates
self-assembly
Online Access:http://www.mdpi.com/1999-4923/11/3/130

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