Visualization of Chromatin Decompaction and Break Site Extrusion as Predicted by Statistical Polymer Modeling of Single-Locus Trajectories

Visualization of Chromatin Decompaction and Break Site Extrusion as Predicted by Statistical Polymer Modeling of Single-Locus Trajectories

Chromatin moves with subdiffusive and spatially constrained dynamics within the cell nucleus. Here, we use single-locus tracking by time-lapse fluorescence microscopy to uncover information regarding the forces that influence chromatin movement following the induction of a persistent DNA double-stra...

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Bibliographic Details
Main Authors: Amitai, Assaf, Seeber, Andrew, Gasser, Susan M., Holcman, David
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Format: Article
Language:en_US
Published: 2211-1247 2017
Online Access:http://hdl.handle.net/1721.1/109829
https://orcid.org/0000-0002-8594-6529

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