PBPK Modeling Approach to Predict the Behavior of Drugs Cleared by Metabolism in Pregnant Subjects and Fetuses

PBPK Modeling Approach to Predict the Behavior of Drugs Cleared by Metabolism in Pregnant Subjects and Fetuses

This study aimed to develop a physiologically based pharmacokinetic (PBPK) model that simulates metabolically cleared compounds’ pharmacokinetics (PK) in pregnant subjects and fetuses. This model accounts for the differences in tissue sizes, blood flow rates, enzyme expression levels, plasma protein...

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Detalhes bibliográficos
Main Authors: Maxime Le Merdy, Ke Xu Szeto, Jeremy Perrier, Michael B. Bolger, Viera Lukacova
Formato: Artigo
Idioma:English
Publicado em: MDPI AG 2024-01-01
Colecção:Pharmaceutics
Assuntos:
PBPK
pregnancy
metabolic clearance
in silico
Acesso em linha:https://www.mdpi.com/1999-4923/16/1/96

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