Discovery of a novel hybrid coumarin-hydroxamate conjugate targeting the HDAC1-Sp1-FOSL2 signaling axis for breast cancer therapy
Abstract Background Breast cancer is one of the most lethal cancers in women. Despite significant advances in the diagnosis and treatment of breast cancer, many patients still succumb to this disease, and thus, novel effective treatments are urgently needed. Natural product coumarin has been broadly...
Auteurs principaux: | Sujie Zhu, Wenjing Zhu, Kaihua Zhao, Jie Yu, Wenxia Lu, Rui Zhou, Shule Fan, Weikaixin Kong, Feifei Yang, Peipei Shan |
---|---|
Format: | Article |
Langue: | English |
Publié: |
BMC
2024-07-01
|
Collection: | Cell Communication and Signaling |
Sujets: | |
Accès en ligne: | https://doi.org/10.1186/s12964-024-01733-4 |
Documents similaires
-
The Role of HDACs as Leukemia Therapy Targets using HDI
par: Ahmad Ahmadzadeh, et autres
Publié: (2016-02-01) -
KLF14 inhibits tumor progression via FOSL1 in glioma
par: Xiaohua Wang, et autres
Publié: (2025-03-01) -
Design, Synthesis and Biological Evaluation of Novel Coumarin-Based Hydroxamate Derivatives as Histone Deacetylase (Hdac) Inhibitors with Antitumor Activities
par: Feifei Yang, et autres
Publié: (2019-07-01) -
Influence of FOSL1 Inhibition on Vascular Calcification and ROS Generation through Ferroptosis via P53-SLC7A11 Axis
par: Sisi Shao, et autres
Publié: (2023-02-01) -
Small Molecules Targeting HATs, HDACs, and BRDs in Cancer Therapy
par: Donglu Wu, et autres
Publié: (2020-11-01)