Gag-protease-mediated replication capacity in HIV-1 subtype C chronic infection: associations with HLA type and clinical parameters.

Gag-protease-mediated replication capacity in HIV-1 subtype C chronic infection: associations with HLA type and clinical parameters.

The mechanisms underlying HIV-1 control by protective HLA class I alleles are not fully understood and could involve selection of escape mutations in functionally important Gag epitopes resulting in fitness costs. This study was undertaken to investigate, at the population level, the impact of HLA-m...

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Bibliographic Details
Main Authors: Wright, J, Brumme, Z, Carlson, J, Heckerman, D, Kadie, C, Brumme, C, Wang, B, Losina, E, Miura, T, Chonco, F, van der Stok, M, Mncube, Z, Bishop, K, Goulder, P, Walker, B, Brockman, M, Ndung'u, T
Format: Journal article
Language:English
Published: 2010

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