Stereoselective production of dimethyl-substituted carbapenams via engineered carbapenem biosynthesis enzymes

Stereoselective production of dimethyl-substituted carbapenams via engineered carbapenem biosynthesis enzymes

Stereoselective biocatalysis by crotonase superfamily enzymes is exemplified by use of engineered 5-carboxymethylproline synthases (CMPSs) for preparation of functionalized 5-carboxymethylproline (5-CMP) derivatives methylated at two positions (i.e. C2/C6, C3/C6 and C5/C6), including products with a...

书目详细资料
Main Authors:	Hamed, R, Henry, L, Claridge, T, Schofield, C
格式:	Journal article
出版:	American Chemical Society 2016

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