Probing the Binding Mechanism of Mnk Inhibitors by Docking and Molecular Dynamics Simulations

Probing the Binding Mechanism of Mnk Inhibitors by Docking and Molecular Dynamics Simulations

Mitogen-activated protein kinases-interacting kinase 1 and 2 (Mnk1/2) activate the oncogene eukaryotic initiation factor 4E (eIF4E) by phosphorylation. High level of phosphorylated eIF4E is associated with various types of cancers. Inhibition of Mnk prevents eIF4E phosphorylation, making them potent...

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Dettagli Bibliografici
Autori principali: Kannan, Srinivasaraghavan, Poulsen, Anders, Yang, Hai Yan, Ho, Melvyn, Ang, Shi Hua, Eldwin, Tan Sum Wai, Jeyaraj, Duraiswamy Athisayamani, Chennamaneni, Lohitha Rao, Liu, Boping, Hill, Jeffrey, Verma, Chandra Shekhar, Nacro, Kassoum
Altri autori: School of Biological Sciences
Natura: Journal Article
Lingua:English
Pubblicazione: 2016
Soggetti:
Eukaryotic initiation factor
glutamic acid
Accesso online:https://hdl.handle.net/10356/81961
http://hdl.handle.net/10220/41065

Accesso online

https://hdl.handle.net/10356/81961
http://hdl.handle.net/10220/41065

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