Immunogenicity of Stabilized HIV-1 Envelope Trimers with Reduced Exposure of Non-neutralizing Epitopes.

Immunogenicity of Stabilized HIV-1 Envelope Trimers with Reduced Exposure of Non-neutralizing Epitopes.

The envelope glycoprotein trimer mediates HIV-1 entry into cells. The trimer is flexible, fluctuating between closed and more open conformations and sometimes sampling the fully open, CD4-bound form. We hypothesized that conformational flexibility and transient exposure of non-neutralizing, immunodo...

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Bibliographic Details
Main Authors: de Taeye, S, Ozorowski, G, Torrents de la Peña, A, Guttman, M, Julien, J, van den Kerkhof, T, Burger, J, Pritchard, L, Pugach, P, Yasmeen, A, Crampton, J, Hu, J, Bontjer, I, Torres, J, Arendt, H, DeStefano, J, Koff, W, Schuitemaker, H, Eggink, D, Berkhout, B, Dean, H, LaBranche, C, Crotty, S, Crispin, M, Montefiori, D, Klasse, P, Lee, K, Moore, J, Wilson, I, Ward, A, Sanders, R
Format: Journal article
Language:English
Published: Cell Press 2015

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