Effects of WNT1 c.110 T>C and c.505G>T mutations on osteoblast differentiation via the WNT1/β-catenin signaling pathway

Effects of WNT1 c.110 T>C and c.505G>T mutations on osteoblast differentiation via the WNT1/β-catenin signaling pathway

Abstract Background WNT1 c.110 T>C and c.505G>T missense mutations have been identified in patients with osteogenesis imperfecta (OI). Whether these mutations affect osteoblast differentiation remains to be determined. This study aimed to investigate the effects of WNT1 c.110 T>C and c.505G...

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Detalhes bibliográficos
Main Authors: Bashan Zhang, Rong Li, Wenfeng Wang, Xueming Zhou, Beijing Luo, Zinian Zhu, Xibo Zhang, Aijiao Ding
Formato: Artigo
Idioma:English
Publicado em: BMC 2021-06-01
Colecção:Journal of Orthopaedic Surgery and Research
Assuntos:
Osteogenesis imperfecta
Osteoblast
WNT1
Mutation
β-Catenin
Acesso em linha:https://doi.org/10.1186/s13018-021-02495-2

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